Medical and behavioral effects of Toxoplasma gondii
Toxoplasma gondii is a single-celled parasite that causes toxoplasmosis, which is manifested clinically in severe cases by jaundice, vision impairment, and liver and spleen enlargement. The microscopic protozoan is often found encysted in nerve tissue, and proliferative forms and cysts can infect numerous species of birds and many species of warm-blooded animals, which act as intermediate hosts. Feline species are the only definitive hosts for the organism. Cats harbor sexual stages of the parasite in their gastrointestinal tract and shed infectious oocysts in their stool. Intermediate hosts become infected by ingesting the sporulated oocysts from cats. Humans can contract the disease by ingesting inadequately cooked meat (especially lamb, pork, and mutton) of the intermediate hosts that have been infected, or by ingesting oocysts from soil or water contaminated with cat feces. In fact, toxoplasmosis is one of the leading causes of death attributed to food-borne illness, and precautions to ensure food safety must be followed. See also: Parasitology; Protozoa; Saliva-based immunoassay of waterborne pathogen exposure; Sporozoa; Toxoplasmea; Toxoplasmida; Zoonoses