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Editorial Briefing
Amphibians under threat from chytrid fungus

May 2019

Amphibians under threat from chytrid fungus

Collectively, members of the class Amphibia are facing massive reductions in total numbers, and the overall biodiversity of amphibians across the globe is under threat. Scientists have determined that global climate change and habitat destruction are two chief factors responsible for some of the decreases observed in amphibian populations. However, another prime culprit has been discovered—specifically, chytridiomycosis. Chytridiomycosis is a disease caused by the waterborne fungal pathogen Batrachochytrium dendrobatidis (abbreviated as Bd). Since the 1980s, scientists have linked the chytrid fungus to the significant loss of much amphibian biodiversity in many locations around the world. More than 500 amphibian species have suffered total number losses as a result of chytridiomycosis, with at least 90 of these species becoming extinct. In addition, 124 species have suffered a 90% reduction in their populations, endangering their continued existence. Although all amphibian species are thought to be susceptible to chytridiomycosis, frogs and toads (order Anura) have been affected to the greatest degree. See also: Amphibia; Anura; Biodiversity; Endangered species; Extinction; Fungi; Global climate change; Mycology; Origins of modern amphibians

Editorial Briefing
Fungus-like microorganisms of the Oomycota

Jan 2015

Fungus-like microorganisms of the Oomycota

The biflagellate water molds, downy mildews, and other microorganisms classified as members of the Oomycota (also termed Oomycetes) have long puzzled taxonomists. Previously, investigators thought them to constitute a group within the true fungi (of the division or phylum Eumycota), primarily because of their filamentous hyphal growth and the fact that they feed on decaying matter. However, they are now considered to comprise a distinct group of microscopic fungus-like eukaryotes. Some taxonomists assign a class status to the Oomycota within the phylum Heterokontophyta, which otherwise contains mostly algal forms; in contrast, others designate Oomycota as a distinct phylum. See also: Algae; Eukaryotae; Fungal genomics; Fungi; Mycology

Editorial Briefing
Health benefits of shiitake mushrooms

Jan 2014

Health benefits of shiitake mushrooms

The historical use of medicinal mushrooms in the traditional therapies of East Asia has been documented for millennia, and biomedical science is now seeking to validate this ancient mycological knowledge through more rigorous evaluation and testing of the nutritional and medicinal properties of these mushrooms. Because many of the current investigations have confirmed at least some health benefits from the consumption of mushrooms, there has been a concomitant increase in the professional and private cultivation of a number of fungal species. See also: Ethnomycology; Fungal biotechnology; Fungi; Mushroom; Mushroom pharmacy; Mycology

Editorial Briefing
Intestinal wound healing impaired by fungi

Apr 2021

Intestinal wound healing impaired by fungi

The diverse totality of microorganisms regularly found on and in the human body is collectively referred to as the human microbiota or microbial flora, with the largest microbial community in the body residing in the large intestine, or colon. Bacteria comprise most of the normal microbial flora, with fungi and protozoa making up a smaller contribution. Investigators have determined that any loss of health or fitness of microbial flora can be detrimental to the body, resulting in immunological dysfunction and disease. For example, individuals with chronic intestinal diseases—including inflammatory bowel disease, Crohn's disease, and ulcerative colitis—are subject to intestinal inflammation and mucosal damage, leading to losses of the intestine's beneficial flora. To restore normal intestinal function and repair tissue damage, treatment typically involves the use of antibiotics to kill harmful intestinal bacteria that may access the bloodstream. Concomitantly, these antibiotics also destroy some beneficial bacterial components of the intestine's microbial flora (previously diminished by disease-borne inflammation and tissue damage); however, the antibiotics do not affect the small percentage of fungal organisms in the microbiota. Thus, microbial fungi have opportunities to dominate mucosal niches of the intestine. See also: Antibiotic; Bacteria; Colon; Fungi; Gastrointestinal tract disorders; Human microbiota; Immune response in inflammatory bowel disease; Inflammation; Inflammatory bowel disease; Intestine; Microbiology; Microbiome

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