Klaassen, Curtis D., and John B. Watkins III, eds. 2022. Casarett & Doull's Essentials of Toxicology. 4th ed. New York: McGraw-Hill. https://www.accessscience.com/content/book/9781260452297
ISBN:
9781260452297
Copyright © 2022 by McGraw Hill. All rights reserved.
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A Notice -
B Contributors -
C Preface -
UNIT 1: General Principles of Toxicology -
1 The Evolving Journey of Toxicology: A Historical Glimpse -
2 Principles of Toxicology -
3 Mechanisms of Toxicity -
4 Risk Assessment -
UNIT 2: Disposition of Toxicants -
5 Absorption, Distribution, and Excretion of Toxicants -
6 Biotransformation of Xenobiotics -
7 Toxicokinetics -
UNIT 3: Non-Organ-Directed Toxicity -
8 Chemical Carcinogenesis -
9 Genetic Toxicology INTRODUCTION HEALTH IMPACT OF GENETIC ALTERATIONS CANCER AND GENETIC RISK ASSESSMENTS FORMATION OF DNA DAMAGE AND DNA DAMAGE RESPONSE PATHWAYS MECHANISMS OF INDUCTION OF GENETIC ALTERATIONS ASSAYS FOR DETECTING GENETIC ALTERATIONS HUMAN POPULATION MONITORING NEW APPROACHES FOR GENETIC TOXICOLOGY CONCLUSION BIBLIOGRAPHY
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10 Developmental Toxicology HUMAN TERATOGENS AND DEVELOPMENTAL TOXICANTS PRINCIPLES OF DEVELOPMENTAL TOXICOLOGY MECHANISMS AND PATHOGENESIS MATERNAL ADAPTATIONS, METABOLISM, AND TOXICOKINETICS IN PREGNANCY RELATIONSHIPS BETWEEN MATERNAL AND DEVELOPMENTAL TOXICITY DEVELOPMENTAL TOXICITY OF ENDOCRINE-DISRUPTING CHEMICALS REGULATORY ASSESSMENT OF RISK OF DEVELOPMENTAL TOXICITY PATHWAYS TO THE FUTURE BIBLIOGRAPHY
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UNIT 4: Target Organ Toxicity -
11 Toxic Responses of the Blood -
12 Toxic Responses of the Immune System -
13 Toxic Responses of the Liver INTRODUCTION LIVER ANATOMY AND PHYSIOLOGY LIVER PATHOPHYSIOLOGY: TYPES OF LIVER RESPONSES TO CHEMICALS CLASSIFICATION OF LIVER INJURY INITIATION AND PROGRESSION OF HEPATOTOXICITY EXAMPLES OF HEPATOTOXICANTS AND THEIR MECHANISMS OF ACTION DETERMINANTS OF SUSCEPTIBILITY IDIOSYNCRATIC, DRUG-INDUCED LIVER INJURY (IDILI): OCCURRENCE AND MODES OF ACTION CONCLUSION BIBLIOGRAPHY
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14 Toxic Responses of the Kidney -
15 Toxic Responses of the Respiratory System RESPIRATORY TRACT STRUCTURE AND FUNCTION BIOTRANSFORMATION IN THE RESPIRATORY TRACT GENERAL PRINCIPLES IN THE PATHOGENESIS OF LUNG DAMAGE CAUSED BY CHEMICALS ALVEOLAR MACROPHAGE RECEPTORS ACUTE RESPONSES OF THE RESPIRATORY TRACT TO INJURY CHRONIC RESPONSES OF THE LUNG TO INJURY AGENTS KNOWN TO PRODUCE RESPIRATORY DISEASE IN HUMANS EVALUATION OF TOXICANT-INDUCED LUNG DAMAGE BIBLIOGRAPHY
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16 Toxic Responses of the Nervous System -
17 Toxic Responses of the Cornea, Retina, and Central Visual System INTRODUCTION TO OCULAR AND VISUAL SYSTEM TOXICOLOGY EXPOSURE TO THE EYE AND VISUAL SYSTEM EVALUATING CORNEAL, RETINAL, AND CENTRAL VISUAL FUNCTION TARGET SITES AND MECHANISMS OF ACTION: CORNEA TARGET SITES AND MECHANISMS OF ACTION: RETINA TARGET SITES AND MECHANISMS OF ACTION: MITOCHONDRIAL OPTIC NEUROPATHIES (MONS) TARGET SITES AND MECHANISMS OF ACTION: THE CENTRAL VISUAL SYSTEM BIBLIOGRAPHY
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18 Toxic Responses of the Heart and Vascular System -
19 Toxic Responses of the Skin -
20 Toxic Responses of the Endocrine System -
21 Toxic Responses of the Reproductive System INTRODUCTION THE REPRODUCTIVE CYCLE REPRODUCTIVE DEVELOPMENT AND SEXUAL DIFFERENTIATION GAMETOGENESIS NEONATAL DEVELOPMENT INFANTILE DEVELOPMENT PUBERTAL DEVELOPMENT SEXUAL MATURITY TESTICULAR STRUCTURE AND FUNCTION MATING BEHAVIOR IN THE RAT FERTILIZATION IMPLANTATION PLACENTA PREGNANCY PARTURITION LACTATION SENESCENCE ENDOCRINE DISRUPTION (INCLUDING SCREENING AND PUBERTY) TESTING FOR REPRODUCTIVE TOXICITY EVALUATION OF TOXICITY TO REPRODUCTION BIBLIOGRAPHY
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UNIT 5: Toxic Agents -
22 Toxic Effects of Pesticides -
23 Toxic Effects of Metals -
24 Toxic Effects of Solvents and Vapors -
25 Toxic Effects of Radiation and Radioactive Materials -
26 Toxic Effects of Plants and Animals INTRODUCTION INTRODUCTION TO PLANT TOXICITIES TOXIC EFFECTS BY ORGAN CLINICAL STUDY OF PLANT POISONS SUMMARY OF PLANT TOXICITIES INTRODUCTION TO ANIMAL VENOMS PROPERTIES OF ANIMAL TOXINS ARTHROPODS ARACHNIDA CHILOPODA (CENTIPEDES) DIPLOPODA (MILLIPEDES) INSECTA MOLLUSCA (CONE SNAILS) REPTILES ANTIVENOMS POTENTIAL CLINICAL APPLICATION OF VENOMS CONCLUSION BIBLIOGRAPHY
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27 Food Toxicology: Fundamental and Regulatory Aspects INTRODUCTION TO FOOD TOXICOLOGY NATURE AND COMPLEXITIES OF FOOD IMPORTANCE OF THE GASTROINTESTINAL TRACT FOOD CONSTITUENTS AND GENOTYPIC VARIATIONS: NUTRITIONAL IMPLICATIONS OF INTER-INDIVIDUAL GENETIC DIFFERENCES FOOD CONSTITUENTS AND REGULATION OF GENE EXPRESSION FOOD–DRUG INTERACTIONS FOOD SAFETY REGULATIONS IN THE UNITED STATES TOXIC SUBSTANCES IN FOOD FOOD ALLERGY CONCLUSION BIBLIOGRAPHY
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28 Toxic Effects of Calories -
29 Nanoparticle Toxicology INTRODUCTION REGULATORY OVERSIGHT NANOMATERIAL BASICS THE NANOMATERIAL BIOLOGICAL INTERFACE TOXICITY MECHANISMS CAVEATS IN NANOTOXICOLOGY ASSAYS SAFETY CONSIDERATIONS IN NANOMATERIAL DESIGN CASE STUDY: DESIGNING SAFER SUNSCREENS MAMMALIAN TOXICOLOGY CASE STUDY: MWCNT TOXICITY TESTING DESIGNING ALTERNATIVE IN VITRO METHODS FOR SCREENING PULMONARY TOXICITY OF FINE AND NANOSCALE PARTICLES ECOTOXICOLOGY OF ENMS BIBLIOGRAPHY
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UNIT 6: Environmental Toxicology -
30 Ecotoxicology -
31 Air Pollution -
UNIT 7: Applications of Toxicology -
32 Analytical and Forensic Toxicology -
33 Clinical Toxicology -
34 Occupational Toxicology
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