The Ebola virus comprises a group of pathogenic agents that cause severe and deadly hemorrhagic fevers in humans and other primates. During 2014 and 2015, an Ebola virus epidemic in West Africa—predominantly, the countries of Guinea, Liberia, and Sierra Leone—killed more than 11,300 people; it was the worst outbreak of this disease in recorded human history. At that time, the World Health Organization (WHO) declared the Ebola outbreak to be a Public Health Emergency of International Concern (PHEIC), and massive efforts were undertaken to contain the spread of the deadly disease. By early 2016, the affected countries were declared free of Ebola virus transmission, and the epidemic was considered to have ended. However, since then, isolated outbreaks have occurred sporadically, mostly as a result of the virus persisting in survivors after recovery. Most troublesome, though, the Ebola virus was detected in August 2018 in the Democratic Republic of the Congo (DRC) in Central Africa and has since expanded dramatically. It is now the second-largest Ebola outbreak on record. As of June 2019, more than 2000 Ebola cases have been detected, with more than 1350 resultant deaths. See also: Africa; Ebola virus; Ebola virus outbreak in 2014–2015; Exotic viral diseases; Infectious disease; Virus

There is a growing body of evidence that many of the thousands of prescription and over-the-counter medications ultimately make their way into water bodies and drinking-water supplies. Typical wastewater treatment plants may not be effective at removing pharmaceuticals. This is because there are no regulations limiting the release of these substances in the environment and, as a result, the needed treatment technology may not have been investigated or implemented. Knowing the best treatment practices for removing pharmaceuticals from wastewater is important for protecting drinking-water supplies as well as organisms in marine and aquatic environments because many pharmaceuticals are designed to be effective at low concentrations. A new study shows that removal of pharmaceuticals from wastewater is possible, even at very low concentrations, depending on the specific treatment process, according to researchers reporting in Environmental Science: Water Research & Technology (January 2020). See also: Environmental toxicology; Freshwater ecosystem; Marine ecology; Water pollution; Water resources; Water treatment

The benefits of outdoor physical activity (exercise) outweigh the potential harm caused by air pollution except in the most highly polluted cities, according to epidemiological studies reported in the journal Preventive Medicine (February 2016). Exercise provides a number of health benefits, including reduced risks of cardiovascular disease, type 2 diabetes, and some cancers. Cycling and walking, for example, offer not just health benefits but also environmental advantages as pollution-free means of transportation. See also: Air pollution; Cancer (medicine); Epidemiology; Heart disorders; Sports medicine; Type 2 diabetes

The species diversity and ultimate survival of amphibians, one of the major groupings of vertebrate animals, face tremendous challenges today for reasons that are still not entirely understood. Since the 1980s, the pace of amphibian extinction has been alarming, and almost 200 identified species have become extinct. About one-third of all amphibian species have seen dramatic declines in populations, and are now considered to be endangered or threatened with extinction. See also: Biodiversity; Endangered species; Extinction (biology); Extinction of species

Researchers have developed polymeric materials that are able to kill multidrug-resistant bacteria without inducing drug resistance or toxic side effects, according to a report in Nature Communications (March 2018). The polymers, known as guanidinium-functionalized polycarbonates, contain a polycarbonate backbone to which a hydrophobic spacer group carrying a guanidinium C(NH₂)₃⁺ group is attached. The positively charged guanidinium group enables the polymer to be prepared as a water-soluble salt as well as to bind to the negatively charged cell walls of bacteria. After attachment, the polymer penetrates and crosses the cell membrane and then precipitates the proteins and genes in the cytoplasm, effectively killing the bacteria. Antibiotic resistance in bacteria is a serious problem worldwide, with the World Health Organization in January 2018 reporting 500,000 people with suspected antibiotic-resistant infections in 22 countries. See also: Antibiotic; Antibiotic resistance; Antimicrobial agents; Drug resistance; Infectious disease; Polymer

It is estimated that 1 gram of soil can be inhabited by up to 10⁹ microorganisms and approximately 60,000 bacterial species. Moreover, soil harbors a vast reservoir of antimicrobial agents, and soil-dwelling bacteria have played a key role in the introduction of antibiotics to treat infectious diseases. Because these resilient bacteria not only produce antibiotics but also are exposed to other antibiotics produced by surrounding strains in the soil, they have developed diverse mechanisms to survive the toxic antimicrobial compounds created around them. Importantly, these mechanisms of robust resistance to numerous classes of antibiotics often resemble the mechanisms of resistance identified in clinical pathogens, including those that infect humans. Thus, scientists are attempting to find possible correlations between antibiotic resistance in soil bacteria and in infectious agents in humans. If correlations can be found, investigators might be able to predict future signs of clinical resistance to certain antibiotics, providing clinicians with methods to circumvent any potential resistance that may emerge. See also: Antibiotic; Antimicrobial agents; Antimicrobial resistance; Bacteria; Clinical microbiology; Drug resistance; Infectious disease; Medical bacteriology; Microbiology; Pathogen; Soil; Soil microbiology

Antisense drugs are gene-based molecules that inhibit the synthesis of proteins (including proteins that cause specific diseases) by binding to the ribonucleic acids (RNAs) responsible for their formation. Specifically, these drugs are single-stranded short polymers of RNA or deoxyribonucleic acid (DNA), termed oligonucleotides, designed to contain part of the noncoding strand of messenger RNA (mRNA), which is a molecule involved in translating DNA into protein. Antisense medications are therefore capable of hybridizing with and inactivating the mRNA, preventing the associated gene from producing the unwanted protein. With their anticancer, antiviral, and anti-inflammatory therapeutic capacities, these drugs have been applied in the treatment of various genetic disorders and infections, including diabetes, rheumatoid arthritis, cytomegalovirus retinitis (a virally caused form of blindness that occurs often in AIDS patients), asthma, hypercholesterolemia (a genetic derangement of fat metabolism characterized by very high levels of cholesterol in the blood), and numerous cancers. Research is also being conducted on patients suffering from Parkinson's disease and Huntington's disease to determine whether antisense therapy can mitigate the effects of these conditions. See also: Biotechnology; Deoxyribonucleic acid (DNA); Disease; Gene; Genetic engineering; Oligonucleotide; Protein; Ribonucleic acid (RNA)

Soil harbors a vast reservoir of antimicrobial agents. In fact, approximately 80% of all clinically implemented antibiotics are derived from soil-dwelling bacteria. However, many bacteria have evolved methods to evade the effects of various antibiotics and thus have acquired resistance to these chemical substances. Today, the increasing resistance of many common disease-causing bacteria to antibiotics is a global health crisis. Therefore, scientists are seeking to develop new antibiotics that can overcome the resistance capabilities of numerous pathogenic bacteria. Arylomycins are considered to be among the most promising of these new compounds. See also: Antibiotic; Antibiotic resistance; Antibiotic resistance in soil bacteria; Antimicrobial agents; Bacteria; Infectious disease; Medical bacteriology; Microbiology; Pathogen; Public health; Soil; Soil microbiology

The Asian longhorned tick (Haemaphysalis longicornis), also known as the bush tick, is a troublesome parasitic species and is an important vector of disease agents. (Note that vectors are capable of biologically transferring a pathogen from one organism to another.) It also is becoming a problematic invasive species. Specifically, it is invading areas located far from its native region in East and Central Asia and is spreading within the United States. In particular, this arachnid is remarkable because female members can reproduce asexually without mating. Thus, scientists fear that the species will spread rapidly in locations where it has already invaded, thereby transmitting numerous diseases that are potentially harmful to humans and other animals. See also: Acari; Disease; Invasive species; Ixodides; Parasitology; Pathogen; Tick virus diseases; Zoonoses

Recycling or reuse is in most instances environmentally preferable to disposal. Reuse of coal tar as an asphalt-pavement sealant for driveways and parking lots, however, has turned out to be an exception to this rule of thumb. See also: Asphalt and asphaltite; Pavement